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Plegridy – the Latest FDA Approved Disease Modifying Therapy

The FDA announced on August 15, they have given approval to Plegridy for use in the United States for treatment of Multiple Sclerosis.  Plegridy becomes the 11th drug approved by the FDA for use in the US.  Plegridy was approved one month earlier by the European Commission  for use in 28 European countries.

This disease modifying therapy (DMT)  is made by Biogen Idec, and is a peginterferon beta-1a drug. It is an injectable drug, but instead of being given once a week like Avonex, Biogen Idec’s other interferon drug, Plegridy will be injected every two weeks. There is also a difference that Avonex is given intramuscularly whereas Plegridy can be injected subcutaneously (just under the skin).   Plegridy has  the same active ingredient as Avonex but has had a polymer called polyethylene glycol (peg) added to it that allows it to remain in the body for a longer period of time, hence reducing the frequency of the injections.  Biogen Idec releases say they expect the cost of Plegridy to be about the same as Avonex, which is around $59,000 per year.

Among the side effects of interferons can be flu-like symptoms that can make the person feel miserable for a day or more after they have done the injection. Being able to spread those injections further apart with Plegridy will mean fewer days of feeling poorly and can affect many things in the user’s quality of life.  You can find additional  information about dosing and side effects at the National Multiple Sclerosis Society’s  (NMSS) Plegridy news page.

Interferons have been in the lineup of drugs since the introduction of Betaseron  (Interferon-beta-1b) as the very first MS  drug approved in 1993.   Since that time there have been a number of other types of drugs also approved for use, but interferons continue to be represented in the mix.  You might wonder why we need all these MS disease modifying therapies- isn’t there one that proves in studies to be better than the others? The answer, quite simply. is no.  There is great interest in biomarkers, those things in our bodies that make us receptive to one of these drugs more than others.  Many people with MS get lucky and are on a DMT from the beginning that works well in keeping the advancement of MS at bay but others may have to try more than one DMT before finding the one their body responds to best.

Biogen Idec now has Avonex, Tysabri, Tecfidera and Plegridy on the US market as MS drugs to treat disease progression; this gives them a definite advantage in the market share of MS drugs.  The other companies with more than one approved MS drug are Novartis, with their DMT’s  Extavia and Gilenya, and EMD Serono with Rebif and Novantrone.

The other approved disease modifying therapy (DMT) drugs and their manufacturers are:

Aubagio, Genzyme

Betaseron, Bayer Health

Copaxone, Teva Pharmaceutical

The options of drugs and flexibility in treatment of multiple sclerosis, from oral pills to injections and infusions, continues to expand and there are many more treatments in the pipeline from other pharmaceutical companies that can’t be far behind in looking for their own approval. We are fortunate to be in a time when there are so many treatments available – 1993 wasn’t so long ago when there was great excitement at the arrival of our first  MS DMT, and now we have eleven choices, with the approval of Plegridy.

Wishing you well,

Laura

 

NOTE: this is a corrected version, which updates the information that Immunex no longer controls Novantrone and that it is part of EMD Serono’s portfolio.

This article represents the opinions, thoughts, and experiences of the author; none of this content has been paid for by any advertiser. The MultipleSclerosis.net team does not recommend or endorse any products or treatments discussed herein. Learn more about how we maintain editorial integrity here.

Comments

  • stukawife
    5 years ago

    This is good news. I took Avonex for 6 years, I tried Betaseron and Rebif….but the needles every other day or IM’s once a week is just not happening anymore. But SubQ every two weeks I can do. I’m taking Tecfidera now….but I still feel a decline, and I did so well on Avonex. At my next Neuro appt I will definately bring this up.

  • stukawife
    5 years ago

    Yes I suppose to leave pills for shots sounds odd, but really it was the frequency of shots that made me look elsewhere, not the effectivensss.

  • Laura Kolaczkowski author
    5 years ago

    Options are a good thing, aren’t they? It is rare we hear anyone say they would go back to injections from the pills, but you are right about being on the therapy that works best for you. good luck, Laura

  • Sonya
    5 years ago

    Laura,
    Thank-you so much for the informative article! I had heard about the new drug, but didn’t know any specifics.
    I was diagnosed 8 years ago, & have been on Avonex ever since. Except for the flu like symptoms, which have all but disappeared, unless I am under the weather with a cold or slight infection of some kind, I have done very well on the injections. This however sounds intriguing!! Injecting once every two weeks, & under the skin, not in a muscle….hey, if you have to inject…this sounds good! I will definitely be researching this one further!
    I so appreciate all you do to keep us up to date on “all things MS”.
    Thanks again,
    Sonya

  • Laura Kolaczkowski author
    5 years ago

    Sonya, perhaps this will be a good option for you to change to- I personally like the ‘less is more’ approach to taking these meds. That might be why i appreciate my once a month therapy. 🙂

    I understand many people get over the flu-like side effects after a while on the interferons and I’m glad you are one of them. You have too many things to do to be down feeling bad. best, Laura

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