What medications are people taking for MS fatigue and how are they working?

Community Answers

  1. DaleneK says:

    I am on Provigil 200 mg. twice a day, I tried Nuvigil, but there was no difference, so back to Provigil, which is slightly cheaper. I don’t feel like the Provigil is helping all that much, but many of the other meds I take have drowsiness as a side effect. I have found that if I am up and moving it helps. If I sit down, even doing an activity, in a matter of minutes I am out!

  2. CatDancer says:

    Yes! I use Dexedrine extended release spansules, and sometimes take an Adderall booster at noon if need be. Vyvanse is by far the best drug I’ve taken for this but it’s fairly new, expensive, and difficult to get your insurance to pay for. Best of luck.

  3. JKeith says:

    Concerta 54mg. It’s an ADHD drug but it keeps me from needing a nap most days.

  4. PetieJ says:

    Hi Poetgirl! Of all the things I’ve been given, Adderall XL 30mg is what helps me move every day. My pcp recently gave me phentermine to try for weight loss bcuz Nothing was working. The combo was amazing! For a few days I felt as close as I’ve felt to Me as I have in YEARS. But it didn’t last long. I had a neurologist who retired after seeing her 2 or 3 times. She did know about MS, but her replacement is a sleep specialist. His thing was to get me to try other MS meds. It was also his consensus that a larger dose than 20mg of Adderall (it may have been less) would make no discernable difference. No clue how he came to this conclusion but I had to question the purpose of there being other doses! Ended up getting my script from pcp. I’ve tried provigil but it made me feel ‘crazy’! I’ve now found a neurologist who is MS specialist. Very Important, tho unless they have MS they don’t Know!!! Please forgive my long windedness! (The xl on Adderall makes a dif too)

  5. poetgirrl author says:

    Thanks, Petie! Very helpful. I agree that having a neuro who is an MS specialist is important.

  6. ChristinaH moderator says:

    Hi poetgirrl,
    In addition to other feedback you may get from the community, this article gives tips for managing fatigue, including mentioning the use of the medications Symmetrel or Provigil: https://multiplesclerosis.net/living-with-ms/taking-steps-to-manage-your-ms-fatigue/. I hope this is helpful! Thank you for reaching out!
    Christina, MultipleSclerosis.net Team

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