Tips for an Easier Round of Solu-Medrol

By Lisa Emrich

3 min read

Living with relapsing MS can be challenging and unpredictable. Relapses can be extraordinarily disruptive. One treatment prescribed to help recovery from a relapse is a 3-day or 5-day round of intravenous corticosteroids known as Solu-Medrol (methylprednisolone), or IVSM for short.¹

Solu-Medrol can help to relieve inflammation during an MS relapse.² Since my first event of optic neuritis in 2000, I have undergone more than 7 rounds of IVSM to treat severe MS relapses. Sometimes I've found the negative effects of the treatment can seem almost worse than the relapse, but I’ve learned a few tricks to help avoid some common problems and to make the experience more tolerable.

1. Tiny veins, or a hard stick

Since I have small and hard-to-find veins, I drink plenty of water to stay well hydrated. My infusion nurse may use a heating pad to help “plump up” the veins so that it is easier to get an IV line started, especially since it will need to stay in place for several days. Be sure to protect your IV line by not getting it wet or dislodging it from your vein.

2. Metallic taste

Solu-Medrol can cause a really yucky, penny-like taste in the mouth.³ I recommend sucking on hard candies or mints during the infusion. Jolly Ranchers and LifeSaver Mints are quite effective. I have been told that drinking chocolate milk helps as well.

3. Avoid headache

Some patients may get a headache during or after the infusion.⁴ If you get a headache, you may consider asking the nurse to slow down the drip on following days. An infusion over 60 minutes is too fast for me, but 90 minutes helps to avoid a pounding headache later in the day.

4. Protect your stomach

Solu-Medrol can cause an upset stomach and heartburn. Rather than let this excess acid eat away at your stomach lining, other medicines (such as Zantac) can be helpful.^5,6

5. The cookie monster

Steroids can make you hungry!! Be careful what you eat. Corticosteroids can cause water retention, so I find it best to avoid salty and sugary foods. Some doctors also recommend increasing potassium-rich foods, such as bananas, since the treatment can cause more excretion of potassium. Blood sugar levels may also need to be monitored while on this treatment.^7,8

6. Resting

While some folks may experience a surge of energy, I think it's still important to rest and recuperate. It’s tempting to be an Energizer Bunny for a few days, but I feel like we’ll just end up paying for it later. Listen to your body and try to take it easy.

7. Insomnia

Each time I’ve undergone a round of IVSM, my heart races, my mind wanders, and I can’t sleep. Rather than suffer from less than 3 hours of shut-eye each night during treatment, I’ve taken advantage of sleep medications such as Ambien and Rozerem.

8. Mood swings

Mood swings can be side effects during IVSM treatment.⁹ My family and I have learned that I need lots of patience and gentle understanding while I’m temporarily not in control of my emotions. I may even feel cognitively deficient, almost downright dumb. This is NOT the time to make big decisions, but it is a good time to avoid confrontation.

9. Depression

Given that corticosteroids can bring about mood changes, keep a close eye on your mood if you suffer from depression.⁹ Knowing in advance that your depression might become exaggerated helps tremendously when you feel the tug of that dark hole. Reassure yourself that it’s just a temporary condition and will soon pass.

10. Weakened immunity

Solu-Medrol can also make you more susceptible to illness. I find it best to try to avoid contact with people who are sick, and it is advised to not receive vaccinations unless your doctor gives you permission.⁵ If you do begin to see signs of infection, such as increased fever, chills, rash, and respiratory distress, contact your doctor immediately. I will avoid public places to help protect myself as well.

What are some of your tips to make the IVSM experience easier?

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This article represents the opinions, thoughts, and experiences of the author; none of this content has been paid for by any advertiser. The MultipleSclerosis.net team does not recommend or endorse any products or treatments discussed herein. Learn more about how we maintain editorial integrity here.

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lightweaver Member
I have had hard veins to stick but learned a simple trick. They go to my upper arm and I have no issues.
1. Erin Rush Community Admin
 I have never heard of that before, lightweaver! Thank you for sharing! Best, Erin, <a href='https://multiplesclerosis.net' target='_blank'>MultipleSclerosis.net</a> Team Member.
CommunityMember108a1e Member
Hello! 😀 I was wondering if anyone has ever experienced this after solu medrol infusion. I feel like each time I have had a solu medrol treatment it is almost like a look into future MS symptoms. For example, after my first solo medrol infusion the first week for me is hard on my body then after I feel pretty good for 3 months or so. But for the rough week symptoms manifest differently each time. I had finger twitching and weakness in my hands and feet- which were new symptoms- then they went away and I didn’t have it again for a while. Now as my MS has progressed I now have those symptoms permanently. It happened this last time I received my treatment and the symptoms that came for the week were not fun and I just hope it’s not a look into my future. I don’t even know if this makes any sense! Haha sorry everyone! 
1. Doreen H Community Admin
 <inline-mention username="CommunityMember108a1e" user-id="6703003"/>, No apologies necessary...we appreciate you reaching out. I do hope others on Solu-Medrol will chime in here with their personal experiences. Treatment can certainly exasperate ones symptoms. It's important to note that everyone responds differently to infusions. Some have shared that they feel like they've been hit by a truck for many days, while others face debilitating fatigue, and others may have a burst of energy. I'm including an article that may provide some helpful insight: <a href='https://multiplesclerosis.net/living-with-ms/feel-after-infusion' target='_blank'>https://multiplesclerosis.net/living-with-ms/feel-after-infusion</a> We always recommend bringing any new or changing symptoms to your healthcare provider's attention. My best, Doreen (Team Member)
2. Erin Rush Community Admin
 <inline-mention username="CommunityMember108a1e" user-id="6703003"/>, I think your comment makes total sense. And you are not the only person that experiences a rough post infusion experience. I wanted to share some articles on the topic of infusions and what to expect (during and post infusion) -- <a href='https://multiplesclerosis.net/living-with-ms/feel-after-infusion' target='_blank'>https://multiplesclerosis.net/living-with-ms/feel-after-infusion</a> and -- <a href='https://multiplesclerosis.net/living-with-ms/tips-for-an-easier-round-of-solumedrol' target='_blank'>https://multiplesclerosis.net/living-with-ms/tips-for-an-easier-round-of-solumedrol</a>. Also, check out the community member comments at the end of each piece for more member experiences on these treatments. All that said, I am a little concerned that your symptoms seem to be sticking around more now. I would definitely talk to your doctor about that, if you haven't done so already. And keep talking about it, especially if you feel like your doctor may not be taking your concerns seriously. I know MS is progressive, so some progression of symptoms is to be expected, but if you feel the rate of progression is picking up speed, please do mention that to your doctor. Best, Erin, Team Member.