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Gad25 ab & Ganglioside Asialo gm1 igG ab - both high?

I am in the middle of being tested for stuff, and most of my searches of various things the last several months brings up MS as a possibility. Several other things have come up, but I don't quite fit any of them.

My neuro wants to do an EMG

I know, I sound ridiculous, but I have been right in the past about a number of health-related things. I have been correct in the diagnoses for my children, too. Anyway, my neuro wants an EMG sooner than the one scheduled in July, and I have heard nothing. I keep messaged them because they told me to, but if not by tomorrow, I must call myself.

MRIs with and without contrast

MRIs with and without contrast will happen in six days (which is just peachy - I feel like the blood is rushing to my head without a pillow on the MRI machine. Although I feel like that in bed as well if I am not at an exact angle).

My GAD25 ab came back rather high

Anyway, I had some bloodwork drawn because my neuro wanted to check for stiff-person syndrome. My GAD25 ab came back rather high, as did my ganglioside Asialo Gm1 IgG antibodies. I want to argue with the SPS idea, due to my reading about it as I don't quite have all the symptoms. And I am having trouble finding solid info about these two things having anything to do with each other.

Could this indicate MS?

My sedimentation rate is just slightly high, but I don't know if that has anything to do with anything else. I know GAD25 has to do with the possibility of some encephalomyelitis form, and from what I understand, MS is one them. However, I look up GAD25, and I only really see journal articles and things that have to do with SPS or Diabetes Type 1 (adult-onset). I don't believe I have Diabetes because apparently the GAD number is too high, but I could be wrong. I am very confused and not very patient because of my symptoms that have been going on for months (probably years, but I won't get into all of that here.) I hope I not completely off here. Thanks.

  1. Hi ! Unfortunately, you will have to wait for the results of your MRI to learn more about whether you have MS. If you have MS, there will likely be lesions on your brain and/or spine. There are so many illnesses with symptoms that mimic MS that it might take a while to get a concrete diagnosis. It will be worth it though. You wouldn't want to be treated for the wrong illness. I am glad you are educating yourself and acting as your own advocate though. Here is an article from our editorial team about the criteria for an MS diagnosis: I hope this helps and that you find relief soon. Please keep us posted! – Lori,, Team Member

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