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For Multiple Sclerosis (MS), the current focus for treatment and research centers around disease-modifying treatments. The are several main goals of disease-modifying treatments that are in development, and/or on the market.  These include improving MS-related symptoms, reducing the frequency of exacerbations, and slowing the progression of disability.  Although there are several different disease-modifying treatments on the market now, their efficacies, tolerabilities, administration routes and frequencies, common adverse effects, and pregnancy-related risks, among other characteristics, are all varied.  Because of this, clinical trials and treatment research continues to be performed in pursuit of the best possible options for those with MS.

How Does the Process Work?

While it may seem like a lot is going on in the research field, it’s important to note that the journey from concept to store or pharmacy shelf is a very slow one.  It can take as long as 10-15 years for a treatment to make it all the way down the “pipeline” and to those who need it.  Understanding this process can also help to understand treatment development as a whole.  The typical steps for a product in development are as follows:

  • Animal Models and Phase I: The very beginning of this process starts by trying out small, single doses on animals and/or healthy volunteers, to ensure basic safety and tolerability
  • Phase II: If Phase I is passed, the focus shifts from solely surrounding basic safety concerns to testing the safety and efficacy of the drug in the target population. The groups used in Phase II are typically mid-sized, and usually does not exceed 200-300 individuals.
  • Phase III: The final step in the trial pathway is Phase III, where large numbers of individuals, usually in the thousands, are included to make a definitive assessment on the treatment in question.
  • Licensing and Approval: If a treatment can make it out of the trial phase, which is often a rare feat—estimated at about 1 or 2 treatments out of every 10,000—it’s data will be presented to appropriate regulatory authorities and agencies, like the US FDA (Food and Drug Administration), to determine if it is cleared for the market, and when it can be made available.
  • Phase IV: Research that takes place after the FDA approves the marketing of a new drug to identify and evaluate the long-term effects of new drugs and treatments over a longer period of time for a larger number of patients

What’s Happening Now?

Currently, there are several treatments making their way down the pipeline that have made it to Phase II and III.  These treatments can be administered orally, intravenously, or by injection, and include monoclonal antibodies, immunomodulators, immunosuppressors, and neuroprotectors.  Regardless of the specific class or mechanism of action, the goal of many of the treatments in the pipeline is to slow down or halt the degradation of myelin, the protective coat on nerve cells, that leads to the progression of symptoms and disability seen in MS.  Since the exact mechanism and cause of MS is unknown, treatment has to follow leading theories.  Although this list is far from exhaustive, several of these theories have led to research centering around:

  • Immunosuppressors: These include antineoplastic drugs, or anti-cancer drugs.  Although MS and cancer are two different conditions, anti-cancer drugs have immunosuppressive effects.  It’s this property that researchers hope will lead to a slowing of myelin degradation.  Anti-cancer drugs could also block the replication of cells responsible for MS decline.
  • Immunomodulators: Although some of these can be immunosuppressors, not all perform the same functions.  There is much research going on currently to determine if B or T immune cells (or both) contribute to MS progression, and how they do so.  Some immunomodulators can act as suppressors and lead to immune cell depletion, while others may increase or modulate immune cell numbers.  Immunomodulators can also affect cytokines, which depending on the specific action, can cause proinflammatory, or anti-inflammatory effects.  Many of these pathways, and the way B and T cells, cytokines, and other immune system components work together are under investigation, and are the targets or immunomodulators.
  • Neuroprotectors: When the brain is under high levels of stress, including inflammation and degradation of neurons, neurodegeneration can take place.  To mitigate some of these pathways of decline, neuromodulators are in development to protect the brain and its related neurological parts, including modulating neurotransmitter function, reducing neurotoxicity, and preserving cognitive function.  Some theories suggest that neurodegradation may be more pressing when it comes to MS progression than inflammatory issues.
  • Monoclonal Antibodies: This subset of treatments can fall under many of the others, but have their own mechanism of action that could be considered the most specific.  Essentially, antibody clones can be created to target very specific cells and cell receptors, thus, marking certain cell types for degradation or upregulation.  Research is going on currently with monoclonal antibodies that deplete B cells, inhibit proinflammatory B cell functions, and inhibit T cell proliferation, among other mechanisms.

Need for PPMS and SPMS Treatments

Ocrelizumab, the first treatment for both RRMS and PPMS, was approved in March of 2017. Until then, pertinent treatments on the market were designated for RRMS only.  Due to the lack of treatment options for PPMS currently available, much research will be designated to researching dual treatments for both PPMS and RRMS, and any additional treatments for PPMS only.  A similar situation is present for SPMS, where mitoxantrone, a chemotherapy drug, is one of the only treatments indicated specifically for SPMS, so there is much research underway to create disease-modifying drugs for this population as well.  There are several treatments for these groups that have already reached Phase II or III, and are still moving along.

Combination Treatments

Regardless of the condition, combination treatments and testing can be a tricky subject.  It’s not hard to envision that two drugs could be better than one, especially if they have complementary mechanisms of action, however, there is also a possibility that two drugs can interact in unexpected ways to produce negative side effects and results, or even cancel one another out.  While combination therapies are used frequently in certain conditions, few trials have been completed or are in progress on combination therapies in MS.  However, even in some of the longest and most extensive trials, combination therapy seemed to be no better than treatment by individual agents, thus far.  Disease-modifying treatments can also have a risky safety profile, and since many of the leading MS treatments fall into this category, safety risks and concerns often overshadow benefits and potential research.  This has led some researchers to explore combinations of one disease-modifying treatment with another nondisease-modifying treatment, such as vitamin D, biotin, or statins.  Nonetheless, combination therapies are still a topic of investigation for MS treatments, although potentially not as attractive and numerous as their solo counterparts.

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