I have RRMS. I wonder if anyone has ever experienced severe hives. Over the past 5 years I have experienced severe outbreaks of hives. It starts in my hands and within minutes spreads to my entire body. Large, angry welps that are very painful. I have to go to the ER because of the pain. I am treated with IV meds: epinephrine, steroids, atarax , benadryl . It goes away. I went a year without another occurrence then out of no where it returned. Over 5 years I probably had 4- 5 episodes. I have had every possible lab run and can find no cause. Some of my labs did point to Lupus but that was ruled out. Thankfully I have been taking monthly Xolair injections and have not had an episode in over a year. The Xolair is very expensive. I carry an epi pens because of the possibility of anaphalactic shock (sp?) I never thought about it being a possible MS symptom. Has anyone ever experienced this?