Anyone have experience with LDN (low-dose Naltrexone)?

HI Echo!

In addition to any community feedback you may get, I thought I would share some information from our site on LDN. This article discusses a variety of MS treatments, including LDN -- https://multiplesclerosis.net/natural-remedies/ccsvi-marijuana-naltrexone-endovascular-procedures-cooling-therapy/. Studies have shown that it can help with pain symptoms and overall mental health, but it does not seem as effective against other physical symptoms besides pain. Here is another article that discusses LDN -- https://multiplesclerosis.net/living-with-ms/using-food-medicine/. While I hope you get more feedback from the community, I hope this information is helpful as well.

Thanks so much for your question and for being a part of the MultipleSclerosis.net community!

Best, Erin, MultipleSclerosis.net Team Member.

I have had rt MS since 1991 and never took meds. However for about 10 years off and on I used it for prevention of exacerbations. As far as I know it was effective. Cost was $25 monthly mailed from a compounding pharmacy in Boca Raton. You have to have a prescription.

I was just prescribed LDN from an Ortho specialist due to my joint pain. He actually diagnosed me with hEDS Hypermobile Ehlers-danlos Syndrome. Ive been extra bendy "double jointed" my whole life. Now that age, menopause and Multiple Sclerosis has caused my muscles to become weaker my joints are hurting, in alot of pain. He suggested Low dose naltrexone as it has pain prevention properties for MS and hEDS. He started me on a upwards taper of 1..5 and in aa few weeks I can up it to 3 to see how I feel. I can already tell a difference in my pain levels and brain fog has lifted. Im excited to see what the possibilities will be. I remember a buzz over ten years ago about LDN and I even bought a book about it. At that time it was not even available in the US. It had to be sent from Israel and was at a higher dosage. When I did get my hands on it I didn't feel any changes and it gave me headaches. I think the trick is in scaling it up from the lowest level. I am looking forward to what changes I see with this route!

I have been on LDN for 5 years or so and can't imagine life without it. I wish more people knew about it. I had to get my PCP to prescribe it because my neurologist refused to prescribe it. I can't really explain or accurately describe exactly how I feel when I take it but I know that at the very least, I sleep better when I take it.