Can MS be diagnosed based on the result of lumber puncture even if contrast brain and spine MRI result is clear?

Hi . The results of a lumbar puncture alone would not likely lead to an MS diagnosis. Here is an article from our editorial team that explains what doctors look for in a lumbar puncture: https://multiplesclerosis.net/diagnosis/lumbar-puncture/. The findings are a clue, but they need to be brought together with other evidence to result in a diagnosis. I hope this helps. Best wishes! - Lori (Team Member)