I used to work as a caregiver for adults with intellectual and developmental disabilities. And in the role I was in, there were times that I had to take the full bodyweight of a resident while trying to assist them. As an 'assisted' home.
With that said, I love your wife's desire and intention. I would personally recommend looking at independent communities versus assisted communities just for the difference in intensity. There are frequently openings for event coordinator positions and community coordinator positions, which focus on (for the former) events hosted in the home/community that bolster the feeling of inclusivity and belonging and (the latter) being a part of the larger community safely and with support.
Every region in the US has a DHSS office that can be a great resource. With your wife having a diagnosis of MS, they may even be able to offer additional services and support for your wife. Also every region has an APS office that not only provides the protective services but links to the community and can facilitate with matching people to people (whether someone in need or someone looking to help). If I were looking to break back in to a role in the field, these would be my first calls.
And for most areas, jobs such as I noted don't really have prerequisites other than a clean background check.
Wishing well 💜💜