Hello... I was diagnosed with CIS in Jan 2014 and with MS in Oct 2016. I started on Tecfidera since Nov 2016. My recent MRI in Oct 2018 showed new, big lesions and an increased size of older lesions. My doctor has suggested Tysabri (only if JC virus antibody is negative). However the same came to be positive and now he has recommended Inj Betaseron thrice weekly. Does the line of treatment seem correct in my case? Did anyone take interferon therapy after taking Tecfidera as first line of treatment? I am too confused as to the next medication that should be taken.