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Has anyone tested positive for the JC Virus during their treatment with Tysabri, Tecfidera, Gilenya, or Ocrevus?

If so, did you continue on that treatment or switch to a drug that does not carry the PML risk?

  1. I'm still JC negative, but I'll tell you my mind is already made up if/when I become positive. I take Tysabri and would continue to take it. While PML is a risk, it really is a small one. Is it scary? Of course, but the risk is low, particularly when compared to the benefits of medication. I've lived with a grandfather who had this disease, I've seen what it can do without a disease modifying treatment, it's far scarier than PML. I also consider Tysabri a literal life saver for me. I honestly don't know if I'd be here without it. Far too many people get overly worried about PML, without worrying about the consequences of MS itself.

    1. Devin, thanks for sharing your experience and views! I hope it'll encourage others to express theirs. We have so many readers fret about PML and ask tons of questions about DMD safety. I'd love it if we could have an ongoing dialogue about it. Best, Kim, moderator

      1. I am newly diagnosed and about to start Tecfidera. I have not yet been tested for JC Virus. I think I'd feel more comfortable knowing before getting started on treatment. Is it not normal practice to test for this before recommending treatment?

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