Hi lazygsd! While I don't have any personal experience with Zinbryta, I do hope you get some feedback from our members that have used this particular medication. Like some of the other medications you have tried, Zinbryta does require regular monitoring to make sure you are not experiencing any serious side effects. I do hope you get some more input from our members and that this medication is a good fit for you! Best, Erin, MultipleSclerosis.net Team Member.