Pediatric Multiple Sclerosis: Can Children Get MS?
It is well-known among the MS community that multiple sclerosis affects women in their 30s about 3 times more than it affects men. But if you have spent time mingling with others in the MS community, you will know that it obviously affects more than just women in their 30s. I mean, I am a guy and I was diagnosed at the age of 20, which is somewhat out of the “norm”. Or is it?
Pediatric MS is uncommon but possible
Well, statistically speaking yes, but people diagnosed at earlier ages than 30 are actually not as uncommon as people may think. However, what is actually uncommon is people under the age of 18 being diagnosed with MS - children. It’s uncommon but not unheard of; according to the National MS Society, children as young as 2 years old have developed MS! This is what is known as pediatric multiple sclerosis, which by definition is MS that affects people 18 years of age and younger.1
It is difficult to diagnose MS in children
Around 3-5% of adults with MS experience their first attack prior to the age of 18, but it is very difficult to diagnose MS in children because the disease mimics so many other diseases such as Acute Disseminated Encephalomyelitis (ADEM) or Transverse Myelitis (TM), which both cause symptoms very similar to MS such as loss of vision, numbness, and loss of balance. Since most pediatricians are not expecting or looking for MS in patients so young, it is often not even considered to be a possibility in the diagnostic process. When MS is considered in these patients, it is more common to actually find clinically definite MS in children older than 11 years of age. But just as most patients are diagnosed between the age of 20 and 40, there are always people outside the average, so sometimes MS is diagnosed in children younger than 11.1-2
Optic neuritis is both eyes is a common symptom
When a child is diagnosed with MS, their disease typically presents just the same as it would in adults with relapsing-remitting multiple sclerosis (RRMS). The most common symptom a child may experience in their first MS attack is bilateral optic neuritis, bilateral meaning in both eyes as opposed to a single eye (unilateral). Not only are children more likely to present with bilateral optic neuritis than adults, but children under the age of 10 are especially more likely to present with bilateral optic neuritis. Not only do children tend to experience the same symptoms as adults with MS, but they also are more likely to experience seizures and personality changes.2
Typical presenting symptoms of pediatric MS
- Visual symptoms such as optic neuritis
- Sensory symptoms such as numbness
- Abnormal gait
- Poor balance
- Heat sensitivity (Uhthoff’s phenomena)
- Lhermitte’s sign
- Bowel and bladder symptoms
Pediatric MS and relapses
An interesting characteristic of pediatric MS is that children tend to experience a higher frequency of relapses than adults, but overall, the disease seems to progress at a slower rate (meaning it takes a child about 10 years longer than an adult to develop permanent disability after their first onset of symptoms).
How pediatric MS progresses compared to adult MS
So, let’s introduce two theoretical patients to help you understand what this means. The first patient noticed their first symptoms when they were 10 years old, and the second noticed their first symptoms when they were 25 years old. Now let’s say the second, older patient started developing irreversible disability at the age of 30. That is 5 years after the onset of their first symptoms. The first and younger patient would statistically take 10 years longer than the second patient to develop permanent disability, which means they would start to develop irreversible symptoms by the age of 25. That is 15 years (10 years longer than 5) longer than it took the older patient to develop permanent disability after the first onset of symptoms, meaning the child’s disease progressed much slower but the child still wound up with permanent disability at a much younger age (25) than the adult (30).
How is pediatric MS treated
Pediatric MS is often treated the same as MS in adults however, many disease-modifying therapies (DMTs) are not actually approved by the Food and Drug Administration (FDA) for use in children under the age of 18.* However, there have been studies conducted by the FDA that suggest that injectable MS therapies (even Tysabri) are safe for use in treating children with MS, and many first-line therapies (such as Copaxone) have proven to be well tolerated in children.3
Many treatments have been used safely
Just like with adults, when a first-line treatment does not seem to be helping, Tysabri (which has been safely used in children just as studies have suggested) is typically the next choice of treatment. Treatments such as corticosteroids, intravenous immunoglobulin (IVIG) and plasmapheresis have also been used on top of a DMT in pediatric MS.3 Just like in adults, the therapies a physician chooses to implement are typically used at the physician’s discretion based on each individual’s disease characteristics, especially since there are currently no criteria for the dosing of these medications in children. Unfortunately, there is currently no data regarding the use of oral DMTs in pediatric MS, and I say unfortunately because we all know how much children just love needles...
Growing up with MS
Multiple sclerosis tends to be a devastating diagnosis for most adults, so I can only imagine how scary MS would be to a child. I definitely feel that it is just so unfair that a child would have to deal with a disease like MS, but after talking to others about this I have had to wonder: would it be easier growing up with a disease or being diagnosed in the middle of life? On one hand, if you are diagnosed that young, you could say you have nowhere to go but up, whereas someone diagnosed at an older age may never be able to do as well as they were doing before their MS. On the other hand, as an adult with MS, I am very happy to have experienced the things that I had in life before my diagnosis, and I personally do not think I would have the same strength to fight this disease had I not experienced all those things. So, personally, I would say I am glad that I had a “normal” childhood, but of course, everyone’s opinion will differ. What do you think?
*Editor's Note: This article was accurate at the time of its publication in August 2015. In May 2018, the first disease-modifying therapy for pediatric MS was approved for children 10 years of age or older.
Were you misdiagnosed with something else before receiving a MS diagnosis?