Anyone experience worsening symptoms on Tysabri?

Hi mser7! I am sorry you are having this issue. Like any treatment for MS, what works for one person may not work as well for another. While Tysabri is a good fit for many people with MS, it just may not be as helpful for others. This piece about Tysabri side effects following infusion (and the comments following the article) give a good luck at Tysabri side effects -- https://multiplesclerosis.net/living-with-ms/the-before-and-after-of-a-tysabri-infusion/comment-page-1/#comments. If you feel that Tysabris is not managing your MS symptoms well, please don't hesitate to discuss this with your physician. There are other potential treatment options you may want to consider. I do hope this helps and that you can speak with your physician about this. Thanks for reaching out and good luck! Best, Erin, MultipleSclerosis.net Team Member.