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What medications are people taking for MS fatigue? How are they working?

Community Answers
  • Seana
    1 year ago

    Hi! I USED to take Adderall 20mg, but now I just deal with it. A year ago I did something I had wanted to do for many years but couldn’t because I have a chronic illness…I fasted for a religious month/holiday. I ended up dropping almost 100 lbs, and considering I weighed OVER 300, I thought that was awesome. I am Muslim, our fast can be difficult if one is ill. There is no eating or drinking or taking in anything from sunrise to sundown. I must admit that I ended up sick as I was so fatigue and it was summer so the sun just was brutal to me. I went into the hospital and hand to have steroids. My Neurologist told me upon seeing her after my release that she thought I was a drug addict and took me off of all my medications except Rebiff and Gabapentin. I am extremely tired and in extreme pain. My legs feel like they are on fire…the burning feeling. I sometimes shake, numbness, and above all just falling out while doing things on computer or writing…helping my kids with homework..terrible. I havent seen my doctor in 6 months to a year. None of my symptoms seem to be worth her attention and there are only so many doctors in the city I can choose from. Its awful to have MS, horrible to have nobody feel your illness is worthy because “there are no donation jar at the grocery check out”, but the worse is to have my children watch me deal with it and be so disappointed…especially when I can’t even stay awake long enough to hear a story or help with homework.

  • DaleneK
    2 years ago

    I am on Provigil 200 mg. twice a day, I tried Nuvigil, but there was no difference, so back to Provigil, which is slightly cheaper. I don’t feel like the Provigil is helping all that much, but many of the other meds I take have drowsiness as a side effect. I have found that if I am up and moving it helps. If I sit down, even doing an activity, in a matter of minutes I am out!

  • CatDancer
    2 years ago

    Yes! I use Dexedrine extended release spansules, and sometimes take an Adderall booster at noon if need be. Vyvanse is by far the best drug I’ve taken for this but it’s fairly new, expensive, and difficult to get your insurance to pay for. Best of luck.

  • JKeith
    2 years ago

    Concerta 54mg. It’s an ADHD drug but it keeps me from needing a nap most days.

  • PetieJ
    2 years ago

    Hi Poetgirl! Of all the things I’ve been given, Adderall XL 30mg is what helps me move every day. My pcp recently gave me phentermine to try for weight loss bcuz Nothing was working. The combo was amazing! For a few days I felt as close as I’ve felt to Me as I have in YEARS. But it didn’t last long. I had a neurologist who retired after seeing her 2 or 3 times. She did know about MS, but her replacement is a sleep specialist. His thing was to get me to try other MS meds. It was also his consensus that a larger dose than 20mg of Adderall (it may have been less) would make no discernable difference. No clue how he came to this conclusion but I had to question the purpose of there being other doses! Ended up getting my script from pcp. I’ve tried provigil but it made me feel ‘crazy’! I’ve now found a neurologist who is MS specialist. Very Important, tho unless they have MS they don’t Know!!! Please forgive my long windedness! (The xl on Adderall makes a dif too)

  • poetgirrl author
    2 years ago

    Thanks, Petie! Very helpful. I agree that having a neuro who is an MS specialist is important.

  • Christina Hegarty PT, DPT moderator
    2 years ago

    Hi poetgirrl,
    In addition to other feedback you may get from the community, this article gives tips for managing fatigue, including mentioning the use of the medications Symmetrel or Provigil: I hope this is helpful! Thank you for reaching out!
    Christina, Team

  • poetgirrl author
    2 years ago

    Thanks, Christina!

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