I am new to this forum as of today and I see that most all these posts are old, I guess this site isn't as popular as a few others I am on, but it looks like a nice one 😀 Anyway, I have intense itching on a pretty regular basis and am in fact going through an episode of it right now. Kim is right, it is from damage to the myelin sheaths surrounding the nerves inside our brain. As many of you may know, this can wreak all kinds of havoc with odd sensations throughout your body-lucky me, I have them all 🙁 Sensations as though tiny bugs are crawling all over me and stinging/biting me at times-this is what generally creates my intense itching from my head to my feet! I also get the burning, severe pain and pins and needles of neuropathy on a regular basis. Numbness/tingling in feet and hands, cheeks and lips (tongue at times) during an exacerbation. I wont go on about all my other symptoms, just mainly wanted to talk about the skin type sensations that are brought about by the nerve damage. Im with Chrissy, it most def affects my quality of life (as does all my MS symptoms that never go away) and I have not found anything to help. I am a big avoider of drugs though, I am only on 3- 1 to save my life and the other 2 so am able to get out of bed and walk. If anyone else has the itching in this way, I'd love to hear from them, especially if you have found something that gives you relief 😀